منابع مشابه
Random timing in signaling cascades
Cells often rely on precise temporal coordination and can go through great troubles to time events in response to internal signals and environmental cues, as demonstrated by circadian clocks, cell-cycle control, and morphogenesis. But for any given set of signals and cues there can also be substantial random variability from cell to cell. The origin of such variation is understood in general te...
متن کاملOscillations in intracellular signaling cascades.
In this paper, we study the oscillatory dynamics of intracellular signaling cascades. We derive a reaction-diffusion model of the mitogen-activated protein kinase cascade, and use it to show how oscillations of the protein kinase concentrations can occur as a function of the depth of the cascade. We find that only cascades with depths of three or more layers undergo oscillatory instabilities. I...
متن کاملCiliary signaling cascades in photoreceptors
For being a polarized neuron and having a sensory cilium, photoreceptors attract remarkable attention. This is due their highly polarized structure and active visual signal transduction cascades and for the enrichment of complex networks of proteins in the cilium. Structural and functional maintenance of the photoreceptor sensory cilium, also called outer segment, ensures that light signal is r...
متن کاملAutoregressive Cascades on Random Networks
This paper considers a model for cascades on random networks in which the cascade propagation at any node depends on the load at the failed neighbor, the degree of the neighbor as well as the load at that node. Each node in the network bears an initial load that is below the capacity of the node. The trigger for the cascade emanates at a single node or a small fraction of the nodes from some ex...
متن کاملAttenuation of noise in ultrasensitive signaling cascades.
Ultrasensitive cascades often implement thresholding operations in cell signaling and gene regulatory networks, converting graded input signals into discrete all-or-none outputs. However, the biochemical and genetic reactions involved in such cascades are subject to random fluctuations, leading to noise in output signal levels. Here we prove that cascades operating near saturation have output s...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2007
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb4100121